Spravato

SPRAVATO® (esketamine) is the first FDA-approved nasal spray medication, taken with an oral antidepressant, for treatment-resistant depression in adults who’ve tried two or more antidepressants* without sufficient relief.

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What is Spravato?

SPRAVATO® is the first FDA-approved nasal spray medication, taken with an oral antidepressant, for treatment-resistant depression in adults.

If you’ve tried two or more antidepressants* without sufficient relief, talk to your healthcare provider to see if you may have treatment-resistant depression. SPRAVATO® is not for use in children and individuals who are pregnant or planning to become pregnant.

How does Spravato work?
  • Spravato is administered as a nasal spray
  • Upon nasal administration, it is rapidly absorbed into the bloodstream and reaches the brain.
  • Spravato targets the N-methyl-Daspartate (NMDA) receptors, leading to an increase in glutamate levels.
  • This process is believed to help restore synaptic connections between neurons and reverse the effects of depression.
  • Spravato is believed to work differently than currently available oral antidepressants.
  • Spravato is taken with an oral antidepressant.

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Treatment Plan
  • You will not be able to drive, so plan transportation for treatment days.
  • You will administer the nasal spray yourself under the supervision of a healthcare provider.
  • You’ll be monitored for side effects for at least two hours.
  • Your healthcare provider will tell you when it’s okay to leave.
  • Do not drive, operate machinery or do anything where you need to be completely alert until the day after a treatment session, following a restful sleep.

Please click here to download Spravato Treatment Plan.

SPRAVATO® (esketamine) | Official Patient Website

Side effects of Spravato
  • Dissociation • Dizziness • Nausea • Feeling sleepy • Spinning sensation • Numbness • Feeling anxious• Lack of energy • Increased blood pressure • Vomiting • Feeling drunk • Feeling very happy or excited

If these common side effects occur, they usually happen right after taking SPRAVATO® and go away the same day.

SPRAVATO® may cause serious side effects including:

  • Feeling sleepy (sedation) • Feeling disconnected from yourself, your thoughts, feelings and things around you (dissociation) • Abuse and misuse • Increased risk of suicidal thoughts and behavior • Temporary increase in blood pressure that may last about four hours after a dose • Problems with thinking clearly • Bladder problems

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Doctors answer patients’ top 9 questions about SPRAVATO®. Be sure to watch the entire video to get the full SPRAVATO® story, including safety information.

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SPRAVATO® helped Nicole’s treatment-resistant depression. Now, she’s resuming her education and sharing her story.

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Contact us today for a consultation to see if Spravato is right for you.

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Patient Testimonials

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Frequently Asked Questions

What is Spravato (esketamine)?

  • Spravato is a nasal spray medication containing esketamine, a form of ketamine. It is approved by the FDA for the treatment of adults with treatment-resistant depression.

How does Spravato work for treating Treatment-Resistant Depression (TRD)?

  • Esketamine, the active ingredient in Spravato, is believed to work differently from traditional antidepressants. It modulates glutamate, a neurotransmitter associated with mood regulation, to help alleviate symptoms of depression.

Who is a candidate for Spravato treatment?

  • Spravato is typically prescribed for adults with treatment-resistant depression, meaning they have not responded adequately to at least two different antidepressant treatments.

What is the treatment procedure for Spravato?

  • Spravato is administered as a nasal spray under the supervision of a healthcare professional in a certified treatment center. The initial treatment phase may involve twice-weekly sessions, followed by a maintenance phase with less frequent administration.

Are there any side effects of Spravato?

  • Common side effects may include dissociation, dizziness, nausea, and an increase in blood pressure. It’s important to report any side effects to the healthcare provider.

How soon can one expect to see results with Spravato?

  • Individual responses may vary, but some patients may experience improvements in symptoms within a few weeks of starting Spravato treatment.

Can Spravato be used in combination with other antidepressants?

  • In some cases, Spravato may be prescribed in conjunction with an oral antidepressant. The healthcare provider will determine the most appropriate treatment plan based on individual needs.

Is Spravato covered by insurance?

  • Coverage may vary, and it’s crucial to check with your insurance provider. Some plans may cover Spravato for the treatment of treatment-resistant depression.

How long is a typical Spravato treatment session?

  • The administration of Spravato typically takes about 1-2 hours, including monitoring time after the nasal spray is given.

Are there any contraindications for Spravato?

  • Certain medical conditions may be contraindications for Spravato use. It’s important to inform the healthcare provider about any existing health issues or medications to ensure safety.

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Always consult with a qualified healthcare professional for personalized information and advice related to Spravato and its potential benefits for treating Treatment-Resistant Depression (TRD).